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In hypertensive subjects with uncontrolled blood pressure on two to four classes of antihypertensive agents ( n = 36) tadalafil reduced mean ABPM systolic and diastolic blood pressure by 7.5 mmHg (95% CI 5.4, 9.6; P 0.01) and 4.3 mmHg (95% CI 6.1, 8.9; P 0.01) compared with placebo. Tadalafil is a medication used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. It does not raise blood pressure, but it may interact Physicians should discuss with patients the contraindication of tadalafil with regular and/or intermittent use of organic nitrates. Patients should be counseled that concomitant use of tadalafil with nitrates could cause blood pressure to suddenly drop to an unsafe level, resulting in dizziness, syncope, or even heart attack or stroke. Serious side effects of Tadalafil. Along with its needed effects, tadalafil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking tadalafil: Less common. Arm, back, or jaw pain does tadalafil raise blood pressure Cialis (tadalafil) is generally safe to use with most blood pressure medications, but not with nitrates or alpha blockers. Learn about the risks of hypotension, dizziness and heart attack when combining Cialis with these drugs.

They found that blood pressure for those taking tadalafil decreased by an average of 1.6/0.8 mm Hg more in the tadalafil group than the placebo group. A decrease in blood pressure is more likely when tadalafil is combined with other medications that can lower blood pressure. Potentially clinically significant decreases in blood pressure after a single oral dose of tadalafil 5 mg (n = 50), tadalafil 10 mg (n = 50), or placebo (n = 51) in patients with coronary artery disease. DBP = diastolic blood pressure; SBP = systolic blood pressure. p 0.01 vs placebo; p 0.05 vs placebo, by 2-sided McNemar test. They found that blood pressure for those taking tadalafil decreased by an average of 1.6/0.8 mm Hg more in the tadalafil group than the placebo group. A decrease in blood